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KMID : 0366219880230020373
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Korean Journal of Hematology
1988 Volume.23 No. 2 p.373 ~ p.379
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The Additive Effect of Recombinant r-Interferon on the Chronic Myelogenous Leukemia Patients Under Conventional Chemotherapy
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Park Chong-Won
Park Tae-Keun
Kim J.-C.
Han Chi-Hwa
Kim Choon-Choo
Kim Dong-Jip
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Abstract
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Gamma interferon has known to suppress normal as well as chronic myelogenous leukemia CFU-GM. We studied the therapeutic effect of recombinant r -lFN on the CML patinets under conventional chemotherapy, 29 patients with CML (chronic 18, advanced 11) were treated with recombinant r-IFN 0.2 ㎎/day (2×106 IU/day) by daily subcutaneous injection for more than 6 months. Among 18 patients in chronic phase, 9 (50%) achieved complete hematological response and 8 (44%) showed partial responses. 4 (36%) out of 11 advanced disease responded partially.
In responding patients, the r-IFN reduced the requirment of hydroxyurea and prolonged the duration of responses.
The age and sex did not affect the response rate to the r-IFN therapy. But, there was tendency of increased response rate by early introduction of r-IFN to the chronic phase of CML. Although our observation period was short, our result indicated that r-IFN affect synergistically to the conventional chemotherapy for the patient with CML.
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KEYWORD
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